The Venous Lymph Node Flap: Concepts, Experimental Evidence, and Potential Clinical Implications.
Identifieur interne : 000A27 ( Main/Exploration ); précédent : 000A26; suivant : 000A28The Venous Lymph Node Flap: Concepts, Experimental Evidence, and Potential Clinical Implications.
Auteurs : Giuseppe Visconti [Italie] ; Thomas Constantinescu [Taïwan] ; Pei Yu Chen [Taïwan] ; Marzia Salgarello [Italie] ; Gianluca Franceschini [Italie] ; Riccardo Masetti [Italie] ; Hung-Chi Chen [Taïwan]Source :
- Journal of reconstructive microsurgery [ 1098-8947 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Lymphoedème.
- Animaux, Lambeaux chirurgicaux, Microchirurgie, Modèles animaux de maladie humaine, Noeuds lymphatiques, Rat Wistar, Rats.
English descriptors
- KwdEn :
- MESH :
- blood supply : Lymph Nodes, Surgical Flaps.
- methods : Microsurgery.
- pathology : Lymphedema.
- transplantation : Lymph Nodes.
- Animals, Disease Models, Animal, Rats, Rats, Wistar.
Abstract
Background Traditionally, lymph node flaps (LNF) have been designed as arteriovenous flaps, with little attention given to the functional anatomy of lymphatic system included in the flap. Based on the anatomical and physiological features of lymphatic system, we believe that a new concept of LNF, the venous LNF, should be investigated. In this article, we report the concepts and findings of venous LNF, and help gauge its potential clinical application in the treatment of lymphedema. Methods Eight healthy Wistar rats underwent cervical LNF harvesting along the right external jugular vein, right inguinal node clearance, and venous LNF transfer in a flow-through fashion along the femoral vein. At 45 postoperative days, the restoration of lymphatic continuity with surrounding tissue was verified with intradermal injection of 0.1% of methylene blue. The flaps were then excised and sent for histologic evaluation. Results All rats survived uneventfully in the postoperative period and no postoperative complications were experienced. The venous anastomosis was proven to be patent clinically. In all rats we found reestablishment of lymphatic continuity with surrounding tissues. Histologically, the nodes showed the following main histoarchitectural changes: drastic reduction of the stromal compartment and preservation of the lymphatic/sinus and vascular compartments. Conclusions The novel venous LNF flap is able to restore lymphatic continuity with surrounding tissue. As healing occurs, the lymph nodes undergo major histoarchitectural changes. The venous LNF has unique theoretical advantages over arteriovenous LNFs. Further investigations would be beneficial to understand its potential in the surgical treatment of lymphedema.
DOI: 10.1055/s-0036-1584527
PubMed: 27326800
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000761
- to stream PubMed, to step Curation: 000761
- to stream PubMed, to step Checkpoint: 000761
- to stream Ncbi, to step Merge: 008452
- to stream Ncbi, to step Curation: 008452
- to stream Ncbi, to step Checkpoint: 008452
- to stream Main, to step Merge: 000A28
- to stream Main, to step Curation: 000A27
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Venous Lymph Node Flap: Concepts, Experimental Evidence, and Potential Clinical Implications.</title><author><name sortKey="Visconti, Giuseppe" sort="Visconti, Giuseppe" uniqKey="Visconti G" first="Giuseppe" last="Visconti">Giuseppe Visconti</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Constantinescu, Thomas" sort="Constantinescu, Thomas" uniqKey="Constantinescu T" first="Thomas" last="Constantinescu">Thomas Constantinescu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Yu" sort="Chen, Pei Yu" uniqKey="Chen P" first="Pei Yu" last="Chen">Pei Yu Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology and Cytodiagnosis, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Histopathology and Cytodiagnosis, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Salgarello, Marzia" sort="Salgarello, Marzia" uniqKey="Salgarello M" first="Marzia" last="Salgarello">Marzia Salgarello</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Franceschini, Gianluca" sort="Franceschini, Gianluca" uniqKey="Franceschini G" first="Gianluca" last="Franceschini">Gianluca Franceschini</name><affiliation wicri:level="1"><nlm:affiliation>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Masetti, Riccardo" sort="Masetti, Riccardo" uniqKey="Masetti R" first="Riccardo" last="Masetti">Riccardo Masetti</name><affiliation wicri:level="1"><nlm:affiliation>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hung Chi" sort="Chen, Hung Chi" uniqKey="Chen H" first="Hung-Chi" last="Chen">Hung-Chi Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27326800</idno><idno type="pmid">27326800</idno><idno type="doi">10.1055/s-0036-1584527</idno><idno type="wicri:Area/PubMed/Corpus">000761</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000761</idno><idno type="wicri:Area/PubMed/Curation">000761</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000761</idno><idno type="wicri:Area/PubMed/Checkpoint">000761</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000761</idno><idno type="wicri:Area/Ncbi/Merge">008452</idno><idno type="wicri:Area/Ncbi/Curation">008452</idno><idno type="wicri:Area/Ncbi/Checkpoint">008452</idno><idno type="wicri:Area/Main/Merge">000A28</idno><idno type="wicri:Area/Main/Curation">000A27</idno><idno type="wicri:Area/Main/Exploration">000A27</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Venous Lymph Node Flap: Concepts, Experimental Evidence, and Potential Clinical Implications.</title><author><name sortKey="Visconti, Giuseppe" sort="Visconti, Giuseppe" uniqKey="Visconti G" first="Giuseppe" last="Visconti">Giuseppe Visconti</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Constantinescu, Thomas" sort="Constantinescu, Thomas" uniqKey="Constantinescu T" first="Thomas" last="Constantinescu">Thomas Constantinescu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Pei Yu" sort="Chen, Pei Yu" uniqKey="Chen P" first="Pei Yu" last="Chen">Pei Yu Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Histopathology and Cytodiagnosis, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Histopathology and Cytodiagnosis, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Salgarello, Marzia" sort="Salgarello, Marzia" uniqKey="Salgarello M" first="Marzia" last="Salgarello">Marzia Salgarello</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Centre for Surgical Treatment of Lymphedema, Department of Plastic and Reconstructive Surgery, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Franceschini, Gianluca" sort="Franceschini, Gianluca" uniqKey="Franceschini G" first="Gianluca" last="Franceschini">Gianluca Franceschini</name><affiliation wicri:level="1"><nlm:affiliation>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Masetti, Riccardo" sort="Masetti, Riccardo" uniqKey="Masetti R" first="Riccardo" last="Masetti">Riccardo Masetti</name><affiliation wicri:level="1"><nlm:affiliation>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Breast Unit, Catholic University of "Sacro Cuore," University Hospital "A. Gemelli," Rome</wicri:regionArea><wicri:noRegion>" Rome</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hung Chi" sort="Chen, Hung Chi" uniqKey="Chen H" first="Hung-Chi" last="Chen">Hung-Chi Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of reconstructive microsurgery</title><idno type="eISSN">1098-8947</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Lymph Nodes (blood supply)</term><term>Lymph Nodes (transplantation)</term><term>Lymphedema (pathology)</term><term>Microsurgery (methods)</term><term>Rats</term><term>Rats, Wistar</term><term>Surgical Flaps (blood supply)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Lambeaux chirurgicaux ()</term><term>Lymphoedème (anatomopathologie)</term><term>Microchirurgie ()</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques ()</term><term>Noeuds lymphatiques (transplantation)</term><term>Rat Wistar</term><term>Rats</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Lymph Nodes</term><term>Surgical Flaps</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Microsurgery</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Lambeaux chirurgicaux</term><term>Microchirurgie</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques</term><term>Rat Wistar</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Traditionally, lymph node flaps (LNF) have been designed as arteriovenous flaps, with little attention given to the functional anatomy of lymphatic system included in the flap. Based on the anatomical and physiological features of lymphatic system, we believe that a new concept of LNF, the venous LNF, should be investigated. In this article, we report the concepts and findings of venous LNF, and help gauge its potential clinical application in the treatment of lymphedema. Methods Eight healthy Wistar rats underwent cervical LNF harvesting along the right external jugular vein, right inguinal node clearance, and venous LNF transfer in a flow-through fashion along the femoral vein. At 45 postoperative days, the restoration of lymphatic continuity with surrounding tissue was verified with intradermal injection of 0.1% of methylene blue. The flaps were then excised and sent for histologic evaluation. Results All rats survived uneventfully in the postoperative period and no postoperative complications were experienced. The venous anastomosis was proven to be patent clinically. In all rats we found reestablishment of lymphatic continuity with surrounding tissues. Histologically, the nodes showed the following main histoarchitectural changes: drastic reduction of the stromal compartment and preservation of the lymphatic/sinus and vascular compartments. Conclusions The novel venous LNF flap is able to restore lymphatic continuity with surrounding tissue. As healing occurs, the lymph nodes undergo major histoarchitectural changes. The venous LNF has unique theoretical advantages over arteriovenous LNFs. Further investigations would be beneficial to understand its potential in the surgical treatment of lymphedema.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Taïwan</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Visconti, Giuseppe" sort="Visconti, Giuseppe" uniqKey="Visconti G" first="Giuseppe" last="Visconti">Giuseppe Visconti</name></noRegion><name sortKey="Franceschini, Gianluca" sort="Franceschini, Gianluca" uniqKey="Franceschini G" first="Gianluca" last="Franceschini">Gianluca Franceschini</name><name sortKey="Masetti, Riccardo" sort="Masetti, Riccardo" uniqKey="Masetti R" first="Riccardo" last="Masetti">Riccardo Masetti</name><name sortKey="Salgarello, Marzia" sort="Salgarello, Marzia" uniqKey="Salgarello M" first="Marzia" last="Salgarello">Marzia Salgarello</name></country><country name="Taïwan"><noRegion><name sortKey="Constantinescu, Thomas" sort="Constantinescu, Thomas" uniqKey="Constantinescu T" first="Thomas" last="Constantinescu">Thomas Constantinescu</name></noRegion><name sortKey="Chen, Hung Chi" sort="Chen, Hung Chi" uniqKey="Chen H" first="Hung-Chi" last="Chen">Hung-Chi Chen</name><name sortKey="Chen, Pei Yu" sort="Chen, Pei Yu" uniqKey="Chen P" first="Pei Yu" last="Chen">Pei Yu Chen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A27 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A27 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27326800
|texte= The Venous Lymph Node Flap: Concepts, Experimental Evidence, and Potential Clinical Implications.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27326800" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |